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Inflammation also induces metabolic reprogramming in the liver, prioritizing the synthesis of acute-phase proteins like CRP, while the synthesis of nutritional proteins such as albumin and prealbumin is suppressed

Many patients report falling asleep faster, fewer nighttime awakenings, and improved daytime alertness within the first 23 months of treatment, even as weight loss is still progressing

While there has been some encouraging evidence for cell-based therapies, ongoing studies are needed to better elucidate mechanisms of action, to understand the duration of any beneficial effects, and to address such concerns as tumorigenesis and immune rejection of grafted cells (Chan et al., 2021

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