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It is a well-tolerated compound with a clean safety profile and a genuinely interesting mechanism that, so far, has produced results in humans that fall short of what animal models predicted
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[Abstract] Expression of synaptophysin in mouse brains in Dihexa-treated (1.44 mg/kg and 2.88 mg/kg) APP/PS1 mice
10.2147/vhrm.s1707 152 RichterB.BergerhoffK.LerchC
A study that compared 24 obese patients with MC-4R deficiency to 80 healthy controls (40 obese and 40 lean) found that those with MC-4R mutations consumed significantly more high-fat meals
doi: 10.1016/S2213-8587(20)30113-3 217 FrlichLBlum-DegenDRiedererPHoyerS
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