does semaglutide wear off during the week reddit 4 weeks... : r/Semaglutide OpenEvidence Cofounder Daniel Nadler Is

Monitoring makes sense

That hormonal shift can have all sorts of effects on reproductive systems, body composition, and general well-being

10.1001/archopht.1978.03910050179015 25 HrelecM.KlicekR.BrcicL.BrcicI.CvjetkoI.SeiwerthS.et al (2009)

The Ozempic prescribing information includes a warning about acute kidney injury and worsening of existing kidney problems, and states that "a majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration." The same label tells doctors to counsel patients "of the potential risk of dehydration due to gastrointestinal adverse reactions and take precautions to avoid fluid depletion." The Mounjaro label carries the same class warning and advises doctors to "monitor renal function in patients reporting adverse reactions to MOUNJARO that could lead to volume depletion." It helps to keep this in perspective

The clinical result is a substantial drop in daily calorie intake without the willpower fatigue that wrecks most diet attempts

Antidiabetic drugs, other GLP-1s and some oral drugs are not recommended to be taken simultaneously