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41 In patients with overweight or obesity without diabetes, the SURMOUNT-1 trial showed that tirzepatide 15 mg weekly led to a mean body weight reduction of 20.9% after 72 weeks of treatment, compared with 3.1% with placebo
A number of plaintiffs sued the FDA in 2024, seeking a preliminary injunction to permit ongoing compounding
JAMA 331(5):425-435, 2024
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These unknowns raise the risk of overdose or other severe side effects
In the hepatocytes, MCFAs in their non-esterified form enter the mitochondrial matrix independently of the carnitine transport system (Schnfeld and Wojtczak 2016) unlike LCFAs, thus not requiring the activity of the carnitine acyltransferase-1 or carnitine palmitoyltransferase I, CPT-1
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