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Since nitrous oxide is commonly used for surgery in the elderly, some experts feel vitamin B 12 deficiency should be ruled out prior to its use or prophylactic vitamin B 12 supplementation implemented before and after exposure to the gas (7, 18)

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Yin Z, Albrecht J, Syversen T, Jiang H, Summar M, Rocha JBTda, Farina M, Aschner M (2009) Comparison of alterations in amino acids content in cultured astrocytes or neurons exposed to methylmercury separately or in co-culture

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Additionally, cognitive deficiency was frequently observed, e.g., problems with working memory, concentration, collecting visual memories, and general cognitive abilities