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Eur.J Ophthalmol

These findings are supported by mechanistic investigations that have identified multiple pathways through which environmental toxicants can induce DNA fragmentation in spermatozoa, including oxidative stress, mitochondrial dysfunction, and direct genotoxic effects (67)

The effects were attributed to decreased BBB permeability, suppression of pro-inflammatory cytokines (TNF-a and IL-6), and modulation of excitatory and inhibitory neurotransmitter signalling [151]