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A randomized, double-blind, multicenter trial in HIV patients with non-alcoholic fatty liver disease (NAFLD) found that tesamorelin, dosed at 2 mg daily for twelve months, reduced liver fat and prevented fibrosis progression, while also decreasing hepatic inflammatory gene expression and increasing markers of oxidative phosphorylation findings some researchers have suggested point toward a direct hepatoprotective mechanism that goes beyond simple fat reduction, though this remains an active area of investigation rather than a settled conclusion

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