In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight
GLP-1 therapy helps reduce cravings and appetite, but lifestyle changeslike balanced nutrition and regular activityhelp maximize results
BMI can over and underestimate body fat [archived link] since it doesnt distinguish fat from bone and muscle mass
Duodenal switch: This combines a sleeve gastrectomy (described above) with an intestinal bypass, resulting in the benefits of both the sleeve and Roux-en-Y
PubMed, Florez, Jose C., et al
Certain medications, like Wegovy, were specifically made and approved as weight loss drugs