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He felt fuller after meals and grabbed fewer post-dinner snacks
In HFrEF, an issue remains that because GLP-1 RAs have been shown to modestly increase heart rate (2-3 beats per minute) owing to their chronotropic effects (see Mechanisms) (Sun et al., 2015), GLP-1 RA treatment in HFrEF may be problematic considering that, in line with the use of beta-blockers to ameliorate HFrEF (11, 12), heart rate elevations may result in a worse outcome (Ibrahim et al., 2019)
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GLP-1 is derived from a transcription product of the proglucagon gene gcg , which also encodes GLP-2 and further factors
Caruso I, Cignarelli A, Giorgino F
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