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Studies in which insulin was titrated aggressively to obtain glycemic control resulted in less weight loss

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In the livers of TLR4 knock-out mice there is reduced inflammation even in the presence of hepatic steatosis suggesting that Kupffer cell TLR4 is important in hepatic inflammatory responses to excess FFA loading

Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events

Schneider CA, Rasband WS, Eliceiri KW