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Astrocytes in AD model animals demonstrated up-regulated expression of genes (CPS1, OCT, ASL, ARG1, and ODC1) and metabolites (aspartate, ammonia, urea, putrescine, and GABA) of the urea cycle

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Alternatively, in contexts such as the treatment of brain injuries and hypertension, injection has been the preferred method [29]

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4.4 Socioeconomic burden and the need for cost-effective therapies Beyond its medical impact, AD imposes a substantial socioeconomic burden, affecting patients, caregivers, and healthcare systems