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In conclusion, the occurrence of DFU is closely related to cell dysfunction, low-grade inflammation, and tissue hypoxia induced by hyperglycemia

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221,222 Activation of Akt stimulates -cell proliferation, reduces apoptosis, and enhances insulin secretion by regulating downstream effector molecules like Forkhead box protein O1 (FoxO1) and the glucose transporter type 2 (GLUT2)

Author contributions TR: Conceptualization, Formal analysis, Methodology, Supervision, Visualization, Writing original draft, Writing review & editing

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Es importante sealar que la concentracin no es el nico factor de eficacia: la formulacin galnica, el pH y la presencia de cofactores influyen significativamente en la biodisponibilidad del pptido