Joint pain
Injury recovery Investigated in animal research on recovery from tendon, ligament, and muscle soft-tissue injury
Mechanistic studies would be strengthened by isoform-specific NOS experiments, FAK or paxillin pathway inhibition, VEGFR2 pathway modulation, direct measurement of endothelial and fibroblast markers, and rescue experiments that test whether blocking one pathway prevents downstream effects
Injectable peptides and growth hormone secretagogues address this gap
Further, we studied isoprenaline (75 or 150 mg/kg s.c.) myocardial infarction (1 challenge) and reinfarction (isoprenaline at 0 h and 24 h, 2 challenges) in rats (assessed at the end of the subsequent 24 h period)
Mice treated with intranasal GHK-Cu were able to recall the correct escape hole from visual landmarks in the Box Maze test, and tried 8-10 times fewer escape holes during the final trial compared to their first trial