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Talazoparib monotherapy in metastatic castration-resistant prostate cancer with DNA repair alterations (TALAPRO-1): an open-label, phase 2 trial

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Gut microbiota can convert tryptophan into metabolites such as 5-hydroxytryptamine (5-HT, serotonin) and kynurenine

Its proposed mechanism of action involves interaction with GHS receptors, also known as ghrelin receptors, which are found in the pituitary and hypothalamus