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Vitamin B6-dependent epilepsy is a group of autosomal recessive disorders caused by mutations in the genes for phosphatidylinositol binding protein (PLPBP), acetaldehyde dehydrogenase 4 family member A1 (ALDH4A1), acetaldehyde dehydrogenase 7 family member A1 (ALDH7A1), pyridoxal (amine) 5'-phosphate oxidase (PNPO), and tissue non-specific alkaline phosphatase (TNSALP)

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Anderson and colleagues pooled data from multiple trials and found that 10 grams per day of psyllium reduces LDL cholesterol by an average of about 7%, with higher baseline cholesterol predicting larger reductions

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Consequently, clinicians frequently have to assess CMRFs associated with MASLD in routine clinical practice