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16 At least a 6 mm margin of unaffected tissue should be removed, or referral to a Plastic Surgeon, ENT Surgeon or Dermatologist for Mohs margin-controlled micrographic surgery is recommended for tumours that have one or more of the following features: 16 Greater than 2 cm in diameter Classified as moderately or poorly differentiated Extending into subcutaneous tissues Present on the ear, lip, scalp, eyelid or nose Recurrent Cryotherapy or fluorouracil can be used to treat IEC where the diameter, location or number of lesions make surgery unsuitable (Table 3)