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This estimate has been designated GIGD, gastro-intestinally mediated glucose disposal ( The ultimate question, however, is which hormones are in fact responsible for the incretin effect

Collectively, the incretin hormones account for 5070% of total post-prandial insulin secretion ( GLP-1 is secreted by L-cells found in the ileum, colon and rectum ( GIP is released from K-cells found predominately in the duodenum and proximal gut in response to nutrients

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Phase 1 and 2 trials have recently been published, addressing its efficacy and safety for reducing body weight and improving the glycemic profile of patients with T2D and/or obesity

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