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Alcohol does not chemically destroy an injected peptide or block it from reaching its target in any well-documented way

Phase 2 trial results (48 weeks, adults with obesity): 1 mg dose: 7.2% body weight loss 4 mg dose: 12.9% body weight loss 8 mg dose: 17.3% body weight loss 12 mg dose: 24.2% body weight loss Placebo: 1.6% body weight loss Phase 3 TRIUMPH-4 results: 9 mg dose: 20.0% body weight loss (22.9 kg / 50.5 lbs) 12 mg dose: 23.7% body weight loss (27.2 kg / 60.0 lbs) Placebo: 4.6% body weight loss In a separate phase 3 analysis, retatrutide at the highest dose achieved up to 28.7% weight loss

Antioxid Redox Signal 9:202733, PMID: 17845131 Hinchman CA, Ballatori N (1994) Glutathione conjugation and conversion to mercapturic acids can occur as an intrahepatic process

doi:10.1073/pnas.1519959113 14

All peptides should remain in sealed containers or vials until ready for reconstitution to minimise contamination and humidity exposure

These compounds are detected in blood before fasting and the degree of increase after 58 hr of fasting was moderate (2.03.4-fold increase