Interestingly, SIRT1 inhibition subsequently affects the phosphorylation of AMPK, leading to downstream activation of acetyl-CoA carboxylase, promotes the synthesis of polyunsaturated fatty acids, which serve as substrates for lipid peroxidation and ferroptosis induction (Zhang et al., 2023a)
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Preclinical animal studies should report model standardization, timing of intervention, endpoint definitions, histological or functional scoring criteria, and whether investigators were blinded to treatment group
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Mitochondrion 50:94114 Breitenbach M, Weber M, Rinnerthaler M, Karl T, Breitenbach-Koller L (2015) Oxidative stress in fungi: its function in signal transduction, interaction with plant hosts, and lignocellulose degradation
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