Surplus ROS attack DNA, inducing damage [107], and oxidize proteins, leading to protein misfolding and functional loss [108]
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Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity
This dual action is likely why Mounjaro leads to more weight loss
Superoxide radical production in response to environmental hypoxia in cultured shrimp
Bispecific T-cell engagers, such as DLL3-targeted Tarlatamab, recruit cytotoxic T cells to eliminate chemorefractory small-cell lung cancer, whereas bispecific antibodies and dual-target nanobodydrug conjugates bypass resistance mediated by receptor downregulation and endocytic escape via multipronged antigen engagement [225,226,227,228,229]