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At the molecular level, glutathione exists in two distinct states: a reduced, active form (GSH) and an oxidized, inactive form (GSSG)

Moreover, an abundance of iron and susceptibility to oxidative stress have resulted in the hypothesis that erythrocytes might undergo ferroptosis, an iron-driven ROS-dependent RCD [78]

Freedman JE, Loscalzo J

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While sub-threshold concentrations of each ligand alone did not alter basal spinogenesis, combined sub-threshold concentrations of 30 " M Dihexa and 2.5 ng/ml HGF or 10 " 13 M Nlel -AnglV and 2.5 ng/ml of HGF produced a near ceiling effect, similar to biological responsive doses of each ligand alone (Figure 1 1 A and B)