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Systematic site rotation also reduces the risk of localised lipodystrophy (changes in fat distribution) and the development of persistent lumps or subcutaneous nodules at frequently used injection points

Ethics declarations Ethics approval and consent to participate We declare that all experiments on human subjects were conducted in accordance with the Declaration of Helsinki and that all procedures were carried out with the adequate understanding and written consent of the subjects

Gouw, M

Martinez FJ

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Self-RNAantimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8