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The test examines genetic factors influencing fat oxidation, choline metabolism, and energy production capacity
Note that the treatment protocol of 3 days of treatment followed by 11 days off is much lower than that recommended in the Physician Desk Reference for moderate/severe lead poisoning (21 days of continuous treatment), so it is expected that the treatment regimen used in this study would have fewer side-effects than for a 21-day treatment regimen
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Specifically, carriers of GIPR variants that are pharmacologically classified as loss-of-function variants with reduced cell surface expression, cAMP production, beta arrestin 2 recruitment, internalization, and endosomal signaling have consistently been associated with lower adiposity-related traits, including BMI (103) and nominally lower prevalence of obesity (39, 9799)
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10.1136/annrheumdis-2012-202218
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