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For example, high levels of SLC7A11-mediated Cys 2 import, in conjunction with the GSH-independent thioredoxin (Txn) system, can substitute for the essential function of the GSH-GPX4 lipid peroxide metabolic pathway in some cells both in vitro and in vivo [4244]

Cognitive impairment was previously assessed by the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) 24

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Buchser WJ, Laskow TC, Pavlik PJ, Lin HM, Lotze MT