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Any patient currently on tirzepatide 15 mg who wants to trial retatrutide should discontinue tirzepatide first, allow at least two weeks for GI recovery, and begin retatrutide at the 2 mg starting dose with standard titration [2][4]

Handling should only be performed by qualified laboratory professionals in controlled research settings with appropriate institutional authorisations in place

Still, the magnitude of the difference, double to quadruple the weight loss percentage, is too large to dismiss as a statistical artifact