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The most common side effects include gastrointestinal related symptoms such as abdominal pain, constipation, diarrhea, nausea, and vomiting

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doi: 10.1038/bjp.2008.100 97 WebsterLRReisfieldGMDasguptaN

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Our findings suggest that SE ameliorates neurodegeneration through a multifaceted mechanism, potentially involving both a peripherally-mediated restoration of the gut-brain axis and a more direct central action that converges on the regulation of sphingolipid homeostasis

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