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For many individuals living with obesity or metabolic challenges, this reward system can become hypersensitive

All patients provided written informed consent before commencement of any trial-specific activity

In addition to maintaining bone quantity , estrogen contributes to improving the quality of bone tissue by supporting the bone matrix the framework that provides structural support

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Clinical trials specifically designed to assess nutrient synergy are also more expensive and require larger sample sizes compared to the trial designs employed in some studies discussed in this review