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Biomedicines 11 (6), 1567

Gastrointestinal adverse reactions nausea, vomiting, diarrhea, abdominal pain and constipation are the most common adverse reactions in this class and the most common reason people discontinue

Theoretically, you could develop health problems if you take an excessively large dose of vitamin B12 supplements all at once

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However, ongoing digestive discomfort may affect eating habits, so managing symptoms can help you stay comfortable throughout treatment

Bottom Line: A high-quality supplement is a powerful tool, but it works best when supported by a nutrient-dense diet and a lifestyle that minimizes unnecessary oxidative stress