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The condition of dark spots found on the skin, especially the face, is more commonly known as pigmentation

[DOI] [PubMed] [Google Scholar] 78.Fullenkamp DE, Rivera JG, Gong YK, et al

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[66] found that the mammalian DNMTs ( Dnmt3a and Dnmt3b ) can also act as Ca 2+ ion- and redox state-dependent active DNA demethylases

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The amount taken depends on your treatment area, but its usually a small amount