This medication works by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways
Efficacy of metformin in obese and nonobese women with polycystic ovary syndrome: a randomized, doubleblinded, placebocontrolled crossover trial
The Vehicle and Baseline control energy intake did not differ significantly from nutritional recommendations based on age and body weight, but the daily energy intake was significantly lower than Vehicle, Baseline, and also the recommended nutritional value for the 5 and 20 g/kg doses of Ex, while it only marginally decreased for the 1 g/kg dose (see Supplementary Table 1 for details)
The dosage is gradually increased to minimize potential side effects, as the body adjusts to the weight loss medication
doi:10.1073/pnas.0502450102
Tirzepatide works by mimicking two metabolic hormones in the body: it acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and also as a glucose dependent insulinotropic polypeptide (GIP) receptor agonist