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The recent commercial availability of gamma-glutamylcysteine means that researchers are now able to successfully test the effectiveness of increasing cellular glutathione (GSH) in treating the symptoms of Long Covid and Chronic Fatigue Syndrome
With respect to any costs/burdens unrelated to data submission, we refer readers to the Regulatory Impact Analysis in section XXVI.C.5
1,2 One of the widely used systemic agents is glutathione, which is a thiol compound and a regulator of the melanogenic pathway in humans
The intracellular GSH pool, present in millimolar concentrations, is involved in various GSH-dependent reactions
For practical purposes, if a patient is on an SSRI or similar antidepressant, they generally must not receive MB unless it is absolutely medically necessary (such as for a life-threatening methemoglobinemia that cannot be otherwise managed)
These groups exhibit distinct substrate specificities
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