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Supplementation with Akkermansia helps increase the expression of mucin, promotes the proliferation and differentiation of goblet cells in the intestinal epithelium, and effectively protects the structure and function of the intestinal barrier

These changes not only support weight control but also contribute to better gut health and overall energy balance

Furthermore, a positive correlation could be observed between MDA levels and the positivity rate of the drug response to leukocyte migration inhibition, a test to confirm the immunological bases of the reaction [72]

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Other key symptoms include cognitive impairment, sleep abnormalities, deep pain in muscle and joints, orthostatic intolerance, headaches, digestive issues, and immune dysfunction [5, 12]