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Several groups have demonstrated that continuous systemic administration of rotenone to rats and mice reproduces key features of PD, including selective degeneration of the nigrostriatal dopaminergic system, activation of astroglia and microglia, formation of cytoplasmic inclusions in neurons, movement disorders, and defects in mitochondrial complex I [11, 14, 57, 62-64]

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Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands

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2023;24:5441 10.3390/ijms24065441

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