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Dec 1989;19(6):730-2

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longum BB 536 demonstrated to modulate the expression of TJPs, with the increase of zonulin-1 and 2, occluding and claudin-1, and to prevent inflammatory damage, in an in vitro model of intestinal barrier developed using Caco-2 cell monolayer [14]

If you live in a warm, dry climate and swim throughout the year, you may experience this condition year-round