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Abrupt withdrawal has been linked to severe complications, including Posterior Reversible Encephalopathy Syndrome (PRES), hypertensive encephalopathy, stroke, and death (Thorpe et al., 2025)

10.1161/JAHA.115.002621 J Am Heart Assoc

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This receptor-level distinction is what mechanistically separates the two, despite both falling under the broader category of growth hormone secretagogue research