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In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity

However, the activity elicited in the presence of spermatozoa could be distinguished from that generated by somatic cells by virtue of the lack of stimulation observed with NEM [37, 54, 55]

Glutathione is the master antioxidant because of its beneficial role in the human body

[PubMed Citation] Gerth K, Ehring T, Braendle M, Schelling P

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