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While it sounds outlandish, medical researchers are beginning to investigate whether these drugs act as a general reward dampener

42 : 8993 Marzo A, Cardace G, Corbelleta C, Bassani E, Morabito E, Arrigoni Martelli E et al

J Neurotrauma (2019) 36(8):135260

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Glutathione helps maintain optimal aquaporin function by protecting these proteins from oxidative damage

It could be stressed, dysfunctional, or out of balance