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However, combination with high-dose ACEI could increase blood pressure

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Effective treatment is occasionally possible for small doses, but must be extremely rapid

This data supports a treatment paradigm in which patients could initiate treatment with potent injectable agents for maximal initial weight loss and then transition to oral orforglipron for long-term maintenance, reducing the burden of chronic injection therapy

A school of medical thought supports people gradually ending their use, but Hong said obesity is generally considered a chronic condition that requires indefinite treatment