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Gunasekaran V, Yuvakkumar R, Ganesan R, Palapetta SC,Gurusamy H

Furthermore, chronic inflammation is recognized as a key factor in inducing insulin resistance, and GPER can modulate intracellular signaling pathways or suppress the expression of proinflammatory cytokines, which reduces the interference of chronic inflammatory responses and improves insulin resistance [1, 34]

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The receptor-mediated transport systems are the most investigated for targeting nanoparticles, the surface of the majority of nanosystems is coupled with BBB receptor ligands