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All four rows describe patients with type 2 diabetes at high cardiovascular risk, namely LEADER, SUSTAIN-6, PIONEER 6, and REWIND, with the REWIND row also noting reduced major adverse cardiac events

PPAR, peroxisome proliferative activated receptor

As reported in a randomized controlled trial, two patients with advanced liver disease, out of 69 patients in the simvastatin group, receiving simvastatin 40 mg/day experienced rhabdomyolysis, with no such sign found in the placebo group (Abraldes et al., 2016)

As such, the GLP-1 pathway has become a major therapeutic target in diabetes, obesity, and cardiometabolic research