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3.1.2 Hepatic First-Pass Metabolism Even if a small amount of GSH enters the bloodstream, it will be quickly taken up and metabolized by the liver

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Although radiotherapy-induced ICD is restricted by the immunosuppressive tumor microenvironment, its combination with immunotherapy effectively diminishes Treg infiltration, facilitates DC maturation, and substantially enhances the abscopal effects of radiotherapy [463, 464]

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