Poly(ADP-ribose) Polymerase 1 represses liver X receptor-mediated ABCA1 expression and cholesterol efflux in macrophages
However, smokers, pregnant or breastfeeding women , and individuals with certain medical conditions such as malabsorption or chronic disease may require higher doses
The dose is equivalent to a years worth or more of oral iron
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ALA may also be effective at slowing damage done by other systemic diseases, but early studies are still being done