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In the normal rats, L-NAME reduced bleeding time (and induced thrombocytopenia and thereby, the NOS-blocker-prothrombotic effect), L-arginine prolonged bleeding time (thereby showing the NOS-substrate-antithrombotic effect) [2931]

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It is presumed that the polar amine and carboxyl groups of L-tyrosine and L-dopa, which are not present in HQ, help to stabilize the substrates through polar interactions with Arg209 in a productive mode (Fig

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