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The recent demonstration of elevated superoxide dismutase, GSH peroxidase, and total antioxidant capacity in COVID-19 outpatients compared to controls could be interpreted as a response to excessive COVID-19-related oxidative stress (Golabi et al., 2022)

Conclusion The apparent disconnect between Se-GSH-Px activity and performance or selenium status indicates that Se-GSH-Px activity might not be a reliable indicator of selenium metabolism

Besides acting as an intermediate in an active DNA demethylation pathway, 5hmC may also serve as a stable neuronal epigenetic mark in its own right [43]

Acknowledgements The authors would like to acknowledge Carlos Martn and Nacho Aguil for the critical reading of the manuscript