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Additionally, as the analysis relied on electronic health records rather than a randomized clinical trial, it cannot establish a cause-and-effect relationship between GLP-1 drugs and improved outcomes

Besides, GLP-1 and GLP-1RAs can interact with other signaling pathways [15]

These effects make it useful in aging and stress adaptation studies

In a significant number of patients, MASLD coexists with other dysmetabolic traits, such as obesity and type 2 diabetes mellitus (T2DM), suggesting that MASLD is the hepatic manifestation of the metabolic syndrome (MetS), impacting approximately 30% of the global adult population [2, 3]