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Semaglutide (marketed as Ozempic ) is a glucagon-like peptide-1 (GLP-1) receptor agonist approved for the treatment of T2DM

Its dramatic age-related decline is significant: plasma concentrations average 200 ng/mL at age 20 but typically plummet to 80 ng/mL by age 60a 60% reduction correlating with visible aging and reduced healing capacity

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Tempia Valenta S, Nicastri A, Perazza F, Marcolini F, Beghelli V, Atti AR, Petroni ML

The GLP-1 sales uplift in these stores is expected to be an enduring benefit, with the average basket size of a GLP-1 customer 40% higher, says CEO Vikesh Ramsunder

Collectively, these results suggest that p53 TAD PEP functions as a peptide inhibitor that targets the FOXO4-p53 interaction