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Further, IL-4 secretion and OVA-specific IgE production were significantly reduced by ginsenoside Rh1 treatment, demonstrating its protection against allergic asthma by suppression of immune cell infiltration and activation of MAPK, Akt, and NFB signaling [218]

This suggests that weight loss improves respiratory function independently of the severity of airway responsiveness, rather than by improving asthma perhaps owing to mechanical issues rather than treating inflammation

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The relationship remains an area of active investigation rather than established clinical practice

Microarray and RNA-seq studies (Pickart & Margolina, 2018

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