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Sitagliptin works by inhibiting the DPP-4 enzyme that destroys GLP and GIP hormones, allowing both to function more effectively

Beta-3 receptors - Found in adipose tissue, or fat cells throughout the body where they play a role in the breakdown of fats

However, most studies indicate that the activation of hepatic stellate cells is an entry ticket to the process of liver fibrosis, resulting in the massive release of a variety of inflammatory factors, cytokines and oxidative stress responses

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Velasquez-Mieyer PA, Umpierrez GE, Lustig RH, Cashion AK, Cowan PA, Christensen M, Spencer KA, Burghen GA: Race affects insulin and GLP-1 secretion and response to a long-acting somatostatin analogue in obese adults

Current level of glycemic control and its associated factors in patients with type 2 diabetes across Europe: data from the PANORAMA study