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The primary endpoints included nitric oxide production, extracellular reactive oxygen species bioactivity, endothelial function, and mitochondrial oxidative stress, with further investigation into the mechanistic role of the oxLDLLOX1 signaling pathway

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AD cases in particular show striking microglial changes, with cells exhibiting marked hypertrophy and forming dense clusters around A plaques [472, 473]

In fact, the literature is still too limited to draw firm conclusions on many topics, as it is based primarily on observational evidence and only minimally on interventional studies, with a scarcity of randomized controlled trials

The result can be premature ageing of the body, including the development of a number of related diseases