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Eventually, when telomeres become critically short, the cell enters senescence: an irreversible state of growth arrest linked to aging and disease [22]

By the time such children or adolescents gain access to medical intervention (which is currently limited at best) or are eligible for clinical trials, the clinical trialist and primary care provider must overcome the years of poor diet, sedentary behavior, and lack of available, safe, and supportive venues for vigorous play and exercise that for the majority of these children paved the way for their conditions

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Gentle hamstring and calf stretches, quad strengthening exercises, and low-impact activities like swimming or cycling typically help

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